VASCSC was started as a facility where people concerned about the quality of science education would come together to try out new ideas and methods for teaching Science. It originated as 'Group for Improvement of Science Education (GISE)' in 1963 from Physical Research Laboratory (PRL), Ahmedabad.

Community Science Centre (CSC) became functional as an independent working space at the current location in 1966. Later it was renamed as 'Vikram A Sarabhai Community Science Centre (VASCSC)' to associate its name with the founder, after his demise in 1971.

In 1991, VASCSC became a registered not-for-profit Society.